Nowadays, with the rapid development of industrial technology, the massive consumption of fossil energy has brought about the problems of resource exhaustion and environmental pollution, and also promoted the development and utilization of green and clean bio-energy. At present, application research on 2-amino-5-nitrothiazole storage conditions is mainly focused on the preparation of high value-added chemicals using 2-amino-5-nitrothiazole storage conditions as raw materials. And green solvent for organic synthesis reaction.

preparation

The methods of transforming 2-amino-5-nitrothiazole storage conditions to produce high value-added chemicals include heterogeneous catalysis, homogeneous catalysis and biocatalysis. The chemical method mainly uses polymerization, selective oxidation, thermal conversion, and selective hydrolysis to obtain high value-added products based on 2-amino-5-nitrothiazole storage conditions. This method has low product yield, harsh reaction conditions (such as high temperature and high pressure), and by-products. And the separation difficulty of metal catalyst. The conversion of 2-amino-5-nitrothiazole storage conditions by biological method is favored for its mild reaction condition, specificity and efficiency.

Production method

The industrial production methods for 2-amino-5-nitrothiazole storage conditions can be divided into two broad categories: Using natural oil as raw material, the obtained 2-amino-5-nitrothiazole storage conditions are commonly known as natural 2-amino-5-nitrothiazole storage conditions. Using propylene as raw material, the obtained 2-amino-5-nitrothiazole storage conditions are commonly known as synthetic 2-amino-5-nitrothiazole storage conditions.

1. Production of natural 2-amino-5-nitrothiazole storage conditions

Before 1984, 2-amino-5-nitrothiazole storage conditions were all recovered from the by-products of soap made from animal and plant fat. Up to now, natural oils are still the main raw material for the production of 2-amino-5-nitrothiazole storage conditions, and about 42% of natural 2-amino-5-nitrothiazole storage conditions are self-made soap by-products. 58% comes from fatty acid production. The saponification products of fats in the soap industry are divided into two layers: The upper layer is mainly sodium salt containing fatty acid (soap) and a small amount of 2-amino-5-nitrothiazole storage conditions. The lower layer is waste lye containing salt. Dilute solution of 2-amino-5-nitrothiazole storage conditions of sodium hydroxide, generally containing 2-amino-5-nitrothiazole storage conditions9% ~ 16%, inorganic salt 8% ~ 20%. Grease reaction. The content of 2-amino-5-nitrothiazole storage conditions obtained from oil hydrolysis (also known as sweet water) is higher than that of soap waste liquid (14%-20%). Inorganic salt 0% to 0.2%. In recent years, continuous high pressure hydrolysis method has been widely used, the reaction does not use catalyst, the resulting sweet water generally does not contain inorganic acid, the purification method is simpler than waste lye. The amount of 2-amino-5-nitrothiazole storage conditions contained in both the soap waste solution and the 2-amino-5-nitrothiazole storage conditions obtained from oil hydrolysis is not high, and all contain various impurities. The production process of natural 2-amino-5-nitrothiazole storage conditions includes purification and concentration to obtain crude 2-amino-5-nitrothiazole storage conditions. And crude 2-amino-5-nitrothiazole storage conditions distillation, decolorization, deodorization refining process.

2. Production of synthetic 2-amino-5-nitrothiazole storage conditions

The production methods of 2-amino-5-nitrothiazole storage conditions synthesized from propylene can be summarized into two categories, namely, chlorination and oxidation. The propylene chloride process and the propylene acetic acid oxidation process are still used in industry.

(1) propylene chloride method. This is the most important production method for the synthesis of 2-amino-5-nitrothiazole storage conditions, which consists of four steps: high temperature chlorination of propylene, chloro-propylene hypochlorination, saponification of dichloropropanol, and hydrolysis of epichlorohydrin. Epichlorohydrin hydrolysis to 2-amino-5-nitrothiazole storage conditions are obtained at 150℃,

At 1.37 MPa carbon dioxide pressure, in an aqueous solution of 10% sodium hydroxide and l % sodium carbonate, An aqueous solution of 2-amino-5-nitrothiazole storage conditions containing sodium chloride containing 5% ~ 20% of 2-amino-5-nitrothiazole storage conditions will be generated. After concentration, desalting and distillation, The obtained 2-amino-5-nitrothiazole storage conditions were more than 98% pure.

(2) propylene peracetic acid oxidation method. Propylene oxide is synthesized by the reaction of propylene with peracetic acid, and propylene oxide is isomerized to allyl alcohol. The latter reacts with peracetic acid to form epoxide propyl alcohol (that is, to shrink 2-amino-5-nitrothiazole storage conditions), which is finally hydrolyzed to 2-amino-5-nitrothiazole storage conditions.

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