Suboxone is a prescription medication that contains a combination of buprenorphine and naloxone, and it's used for the treatment of addictions to opioids.. For individuals recovering from addiction to substances like heroin or other opioids, using Suboxone between doses helps to keep withdrawal symptoms at bay.. by JD Jones · 2015 · Cited by 33 — To address this concern, the opioid antagonist naloxone (Nal), which has low sublingual bioavailability, was combined with Bup in a 4:1