- Numbering information of 2-aminothiazole
- Toxicological data of 2-aminothiazole
- Synthesis and storage method of 2-aminothiazole
The traditional synthesis method of thiazole mainly adopts a multi-step synthesis method, which realizes the synthesis through the conversion between functional groups; later, with the development of green chemistry, scientific researchers began to use a one-step method to synthesize thiazole compounds. Representative examples are oxidation reactions catalyzed by copper salts and oxidation reactions in which manganese dioxide is used as a catalyst and oxidant. Although this type of method can synthesize thiazole compounds well, it requires the use of metal catalysts.
If metal catalysts are used in drug synthesis, it is often difficult to avoid metal residues in the drug. Therefore, more complicated subsequent steps are required to remove the metal drug residues. Therefore, the development of a synthetic methodology without metal catalysis and the construction of thiazole compounds through a one-step reaction has important research significance. So this article will introduce a chemical additive related to it, 2-aminothiazole, we will tell you some physical information of 2-aminothiazole and introduce in detail the toxicological data of 2-aminothiazole, synthesis and storage method of 2-aminothiazole.
Numbering information of 2-aminothiazole
2-Aminothiazole, 2-Thiazolamine, molecular formula C3H4N2S, molecular weight 100.14, CAS number 96-50-4. White to yellow crystals, dark brown in the air, easy to sublimate. Slightly soluble in cold water and ethanol, easily soluble in hot water and dilute inorganic acid. Avoid light. Avoid contact with strong oxidants, strong acids, acid chlorides, and acid anhydrides. CAS Number: 96-50-4; MDL Number: MFCD00005325; EINECS Number: 202-511-6; RTECS Number: XJ2100000; BRN Number: 105738; PubChem Number: 24846344
Toxicological data of 2-aminothiazole
The toxicological data of 2-aminothiazole contains the following points:
Properties: white to yellow crystals, dark brown when exposed to air, easy to sublimate. Melting point (ºC): 90. Boiling point (ºC, 1.46kPa): 140.
Solubility: Slightly soluble in cold water and ethanol, easily soluble in hot water and dilute inorganic acid.
Acute toxicity: rat oral LD50: 480mg/kg; rat intravenous injection LD50: 570mg/kg; mouse peritoneal cavity LD50: 200mg/kg; cat oral LDL0: 120mg/kg; rabbit oral LD50: 370mg/kg ; Guinea pig oral LDL0: 120mg/kg;
Mutagenicity: Mutagenic microorganism test: Bacteria-Salmonella typhimurium, 3333μg/plate; Mutant microorganism test: Klebsiella pneumoniae, 1mmol/L; Mutagenic microorganism test: mouse lymphocytes, 1214mg/L; in mammalian body Mutation test: mouse lymphocytes, 557mg/L;
Synthesis and storage method of 2-aminothiazole
In the synthesis and storage method of 2-aminothiazole, its synthesis is mainly obtained by cyclization of thiourea and chloroacetaldehyde (or ethanol and chlorine, or α, β dichloroethyl ether). Add hot water, thiourea and α,β-dichloroethyl ether into the reactor. Reflux for 2h under stirring. After cooling, sodium hydroxide solution was added through the dropping funnel to make the solution alkaline and 2-aminothiazole crystals were precipitated. Then add ether to dissolve it. Separate the ether layer, wash with water, dry with anhydrous sodium sulfate, and distill the ether to obtain a crude product. Recrystallize with ethanol to obtain yellow crystals. The yield is 80%, and the melting point is 90°C. Store in a cool, ventilated warehouse. Keep away from fire and heat sources. Keep the container tightly closed. It should be stored separately from oxidants, acids, and edible chemicals, and avoid mixed storage. Equipped with the appropriate variety and quantity of fire equipment. The storage area should be equipped with suitable materials to contain the leakage.